MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma
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منابع مشابه
MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma
The microRNA miR-451 is downregulated in gliomas, this has been suggested by several different research groups and is consistent with our data. Our previous study also confirmed that miR-451 has a repressive role in glioma by inhibiting cell growth, proliferation and by inducing cell apoptosis. In the present study, we identified a target gene of miR-451 in human glioma and investigated the mec...
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Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study, our findings indicate that miR-451 is significantly overexpressed in pancreatic cancer tissues and cell lines and elevated expression of miR-451 contribute...
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RATIONALE In some patients with type 2 diabetes mellitus (DM) without hypertension, cardiac hypertrophy and attenuated cardiac function are observed, and this insult is termed diabetic cardiomyopathy. To date, microRNA (miRNAs or miR) functions in diabetic cardiomyopathy remain to be elucidated. OBJECTIVE To clarify the functions of miRNAs involved in diabetic cardiomyopathy caused by type 2 ...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2011
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2011.1306